爱上海419论坛-阿拉上海后花园论坛-上海龙凤shlf1314-夜上海最新论坛社区

On July 23rd, Nature published online the research results jointly completed by the research team led by researcher Zhou Qi from Institute of Zoology, Chinese Academy of Sciences and the research team led by Professor Ceng Fanyi from School of Medicine, Shanghai Jiaotong University. For the first time, they used iPS cells to obtain mice with survival and reproductive ability by injecting tetraploid blastocysts, thus proving the totipotency of iPS cells for the first time in the world.

Using iPS cells to inject tetraploid blastocysts, mice with survival and reproductive ability were obtained.

IPS cells are called induced pluripotent stem cells, which are stem cells induced from somatic cells and have developmental pluripotency similar to embryonic stem cells. In July, 2006, Japanese scientists announced for the first time that they had discovered the method of transforming mouse skin cells into pluripotent stem cells. In November, 2007, American and Japanese scientists induced human cells into iPS cells, which was rated as the top ten scientific and technological progress in the world by Science magazine in 2008. IPS cells have broad application prospects in the fields of biology and medicine, and are expected to become an important cell source for regenerative medicine and cell therapy.

The research of iPS has advanced by leaps and bounds, but do iPS cells really have the same totipotency as embryonic stem cells? Is it really comparable to embryonic stem cells? Embryonic stem cells can develop into normal mice when they are injected into the early embryos of tetraploid mice (embryos that have no further development ability and only provide nutritional environment) and then transplanted into surrogate mothers. Tetraploid blastocyst injection method is the "gold standard" to verify whether cells are totipotent. However, previous studies have found that iPS cells can not develop into living mice through tetraploid blastocyst injection like embryonic stem cells, and all the mouse fetuses formed after iPS cell injection die from early to late pregnancy. These results show that iPS cells are not totipotent yet.

Zhou Qi et al. prepared 37 iPS cells, injected more than 1,500 tetraploid embryos with 6 iPS cell lines, and finally obtained 27 live mice with 3 iPS cell lines. After identification by various molecular biology techniques, it was confirmed that the mice really developed from iPS cells, and some mice have now matured and propagated their offspring. This is the first time in the world to obtain live mice completely prepared from iPS cells, which strongly proves that iPS cells are truly totipotent. This work provides a technical platform for further research on the application of iPS technology in the fields of stem cells, developmental biology and regenerative medicine, pushes the research of iPS cells to a new height, and also makes an important contribution to China in this international hot research field.

　　Recently, soda music is very popular with users, so do you know how to synchronize the vibrato to soda music? The following small series tells you how to synchronize the vibrato video of soda music to soda music. Interested users will take a look at it below.

　　How to synchronize the vibrato video to soda music? Method for synchronously shaking audio and video of soda music to soda music

　　Open soda music to enter my page, and click the [Settings] icon in the upper right corner.

?

　　Click the [Privacy Settings] option, and click the [Synchronize vibrato to soda music] option.

　　Click [Confirm].

　　The above is the way to share the synchronized vibrato of soda music to soda music. More exciting tutorials are in the IT Encyclopedia.

Due to the improvement of watermelon varieties and planting techniques, this year’s local watermelons are listed ahead of previous years. In order to facilitate local melon farmers to sell melons in the city, standardize the behavior of selling melons, and fully meet the needs of citizens’ lives, the Urban Management and Law Enforcement Bureau of our city set up real estate watermelon sales points 20 days earlier than last year, and at the same time ensure the sanitation and order of the city appearance and environment. The city adopted the "three-fixed" method of fixed location, fixed area and fixed responsibility, effectively standardized the sales of real estate watermelons in urban areas, and rationally planned fixed locations. On the basis of fully considering the dual needs of urban management and citizens’ life, 149 temporary watermelon sales points were selected and set up in the urban area this year. From June 1 to August 30, a "watermelon map" was drawn, covering the main areas of the built-up areas such as Langya District, Nanqiao District, Economic Development Zone and Suzhou-Chuzhou High-tech Zone, and the general public, melon farmers and mobile phone new media were informed in time.

Langya district fruit temporary sales store 34 Chu

1. Fengle Avenue (outside the wall of Chengnan Primary School)

2. Mingguang West Road (South Gate of Binhu Community)

3. Fengle Avenue (Fengle Shijia Lane)

4. Fenghuang East Road (at the entrance of Fenghuang Sancun)

5. Lai ‘an Road (Lianhua Lane intersection)

6. Chuangye North Road (Chuangye Beiyuan)

7. The entrance of Alibaba KTV in Ziwei Community

8. Guma Road (at the entrance of Xiaoyuan, Guma Road West)

9. Intersection of Taiping Lane and West Street

10. Door of Peking University Courtyard of Wende Street Municipal Committee

11. Entrance of Beihu Food Market on Nanqiao North Road

12. Fengle Avenue (Zhujin Beiyuan in Nongke Lane)

13. Xijian Road (at the entrance of Hongye Villa)

14. Intersection of Sanliting Road

15. At the entrance of Sanyu Yijingyuan Community

16. Sanliting Road (at the entrance of Hongye Villa)

17. Dingyuan Road (West Gate of Real Estate Garden)

18. Ziwei North Road (at the entrance of Guangming Garden)

19. Langya Road (Langya Road and Jianshe Road Garden)

20. Fengle Avenue (copper mine gate)

21. Mine Road (opposite the south gate of Copper Paradise)

22. Xijian Road (north of the intersection of Xijian Road and Longting Road)

23. Xijian Road Tailian Hospital entrance

24. Xijian Road (next to Chengxin Business on Xijian Road)

25. Yangzi Road (opposite Wuli Food City)

26. Qingliu East Road (Qingliu People’s Gate)

27. Clear water rhyme at the door

28. At the entrance of the Red Third Ring Home

29. Lingxi Road (East Gate of Lingxiyuan)

30. Baoshan Road (the sidewalk opposite Huimin Food Market)

31. Chuhe Road and Huangfushan Road (in front of the North Gate of Century Garden Community)

32. Jinshan Road (the sidewalk in front of Chuangda Yiwu Trade City on Jinshan Road)

33. century avenue (South Gate of Zhongken Logistics Park)

34. Guanshaner Road (the sidewalk on the west side of the intersection of Yangzi Road and Guanshaner Road)

It is estimated to accommodate 177 households.

Nanqiao district fruit temporary sales store 27 Chu

1. Xinsheng Road (north-west side of Xinsheng Road)

2. Nanqiao Road (north and south sides of Daoxiang Road entrance)

3. Nanqiao Road (north of the entrance of Fengqiao Road)

4. Nanqiao Road (both sides of the west gate of the brewery dormitory)

5. Nanqiao Road (Fangang Lane on the south side of No.8 Middle School)

6. Huxin Road (on both sides of the entrance of Mianma Community)

7. Huxin Road (on both sides of Huxin Lane)

8. Huxin Road (both sides of the north gate of Huxin Road Community)

9. Fengle Avenue (opposite the gate of Nanyingfang)

10. Zhongdu Avenue (both sides of the east and west entrance of Fengqiao Road)

11. Zhongdu Avenue (north of the west entrance of Xugang residential group)

12. Fengyang Road (northeast corner of the intersection of Yongfeng Road and Fengyang Road)

13. Longpan Avenue (both sides of the north gate of Tianyi Huafu Guiyuan Community)

14. Longpan Avenue (both sides of the north gate of Longpan Xiyuan)

15. Chuangye Road (south of the intersection of Chuangye Road and Qingliu Road)

16. Chuangye Road (north of the intersection of Chuangye Road and Shanghai Road)

17. Quanjiao Road (East Gate of Mingru Garden)

18. Quanjiao Road (named Confucian Garden Little Square)

19. Tongle Road (northeast and south sides of the intersection of Tongle Road and Yangming Road)

20. Zuiweng Road (North Gate of Ganghui Community)

21. Zuiweng Road (northeast of the intersection of Zuiweng East Road and Chuning Road)

22. Youan Road (East Gate of Tianyi Huafu Zhuyuan)

23. Youan Road (West Gate of Tianyi Huafu Xingyuan)

24. Yongle Road (West Gate of Faneng International City Community)

25. Yangming Road (Siya Neighborhood Central Square)

26. Jingzi Road (both sides of the south gate of Wanqiao Xinyuan)

27. Nanguo Jiayuan Community

It is expected to accommodate 65 households.

Economic development zone fruit temporary sales store 72 Chu

1. Huashan Road (North Gate of Fuchunyuan Community)

2. Fengle Avenue (Sunshine Mediterranean Gate)

3. Shanshui people’s door

4. Shuangyong Road (at the entrance of Trade City)

5. Huifeng West Road (North Gate of Shanshui Renjia Community)

6. Nanqiao Road (50 meters south of the intersection of Nanqiao Road and Lanxu Lane)

7. At the entrance of Jinxiu Garden

8. Southwest of the intersection of Nanqiao Road and Huifeng Road

9. Northwest corner of the intersection of Nanqiao Road and Huashan West Road

10. Northwest of Nanqiao Road and Huashan Road.

11. Northwest of Nanqiao Road and Huating Road.

12. Zhongdu Avenue (at the northeast corner of the intersection of Zhongdu Avenue and Huashan West Road)

13. At the west gate of Ankang Garden.

14. South of the east side of Zhongdu Avenue and Lanxu Lane Road

15. West side of the gate of Huifengyuan

16. The west side of the intersection of Zhongdu Avenue and Lantian Road

17. At the gate of Yukun Regent City.

18. Intersection of Zhongdu Avenue and Mingdu Road

19. East Gate of Hengda Mingdu

20. The northwest of Zhongdu Avenue and Huating Road West.

21. Zi Long Road (at the intersection of Zi Long Road and Huashan West Road)

22. Intersection of Zi Long Road and Mingdu Road

23. Intersection of Zi Long Road and Qifeng Road.

24. Quanjiao Road (east of the intersection of Quanjiao Road and Huashan Road)

25. At the west gate of Zi Long House.

26. Quanjiao Road at the southeast corner of the intersection of Huifeng West Road.

27. Tianan City Garden East West Gate

28. On the east side of the intersection of Quanjiao Road and Lantian Road.

29. At the east gate of Junjia Hotel

30. At the south gate of Tianan City Garden West District.

31. East Gate Exit of Rainbow Community

32. Intersection of Quanjiao Road and Taiyi Road

33. Fengle Avenue (on the east side of the intersection of Huifeng Road and Fengle Avenue)

34. At the west gate of Guiyuan Mountain Villa

35. Opposite Chuzhou College

36. The west side of the road at the intersection of Fengle Avenue and Xueyuan Road

37. Zhengda Feed Factory East Gate

38. The west side of the intersection of Fengle Avenue and Huifeng Road

39. Xijian Road (at the northeast corner of the intersection of Xijian Road and Xueyuan Road)

40. Ziwei Road (southwest of the intersection of Ziwei Road and Yongfeng Road)

41. Northwest of the intersection of Ziwei Road and Tianle Road

42. Fengyang Road (in front of Hange Hotel on Fengyang Road)

43. Northeast of the intersection of Fengyang Road and Tianle Road

44. West Gate of Ziwei Tianyue Community

45. Northeast corner of the intersection of Fengyang Road and Tongle Road

46. Huifeng Road (Tianan Century City North Gate)

47. Yangming Road (northwest of the intersection of Yangming Road and Huating Road)

48. The northwest of Yangming Road and Huayuan Road.

49. Tongle Road (South Gate of Longshan Community)

50. Longshan Road (at the entrance of Longshan Farmers’ Market)

51. Jinling Road (northeast corner of the intersection of Jinling Road and Longshan East Road)

52. Heying Road (northwest of the intersection of Huayuan Road and Yangming Road)

53. Tongle Road (South Gate of Longshan Community)

54. Longshan Road (at the entrance of Longshan Farmers’ Market)

55. Jinling Road (northeast corner of the intersection of Jinling Road and Longshan East Road)

56. Shanghai Road (west entrance of Juxiangyuan Community)

57. entrance to the logistics service center

58. Zhongzhou International Mall entrance

59. Yaxia car entrance

60. century avenue (intersection of century avenue and Heying Road)

61. Yongyang Road (Lixun Industrial Park)

62. Yangzi Road (entrance to Gao Qiao Community)

63. Zhongzhou International Garden Community Entrance

64. Suzhou Road (west gate of Lingdong Jiayuan Community)

65. Jiujiang Road (south entrance of Lingdong Jiayuan Community)

66. Changjiang Road (West Gate of Chengdong Garden Community)

67. East Gate of Chengdong Garden Community

68. Longji Le Ye North Gate

69. Intersection of Changjiang Road and Suchu Avenue

70 Changzhou Road (north of Linlou Trade Market)

71. Nantong Road (north gate of Linlou Community)

72. Haining Road (South Gate of Shimiao Community and the surrounding construction site)

It is expected to accommodate 198 households.

Langyashan scenic spot fruit temporary sales store 11 Chu

1. Zuiweng West Road (at the entrance of traffic driving school)

2. In the parking lot of Studio City Phase II.

3. Erxian Road (in the parking lot of Film and Television City Phase I)

4. Yijing Shancheng Square

5. Xiangsheng Shili Square

6. Minghu Avenue (Happy World)

7. Plan Route 4 (Happy World)

8. Langya Ancient Road (North Gate of Langya Mountain)

9. Guanjing Road (Langyashan East Gate Parking Lot)

10. Chuyang Road (training point)

11. Mingguang West Road (at the entrance of Longchi Garden)

It is expected to accommodate 22 households.

Suchu high technology zone fruit temporary sales store 5 Chu

1. Changzhou Road (northeast of the intersection of Changzhou Road and Dawangying Road)

2. Yangzi Road (intersection of Yangzi Road and Changzhou Road)

3. Dawangying Road (the intersection of Dawangying Road and Jinzhou Road)

4. Lin Zilu (intersection of Lin Zilu and Nanjing Road)

5. Suchu Avenue (Blue White Collar Phase II at the intersection of Suchu Avenue and Wenzhong Road)

It is expected to accommodate 25 households.

Source: Chuzhou Urban Management Law Enforcement Bureau

First trial: Deng Zhonghang

Original title: "Just announced! It involves 149 places in Chuzhou City! 》

Read the original text

Text | Node Finance Six Gold

The listing of Netease Cloud Music caused an uproar in the market, and many people denied this "loss-making business" almost at the first time.

Some people think that it has lost 7 billion in the past three years and still holds a valuation of nearly 50 billion, which is not worth it at all.

Some people think that a company with a negative gross profit margin dares to go public?

Others think that this is another sentimental listing, which is really too weak!

These voices are all reasonable, but they are not quite right when they are placed on Netease Cloud Music.

　Do you think a grid of electricity is weak?

Judging from the "birthday" of Netease Cloud Music, it is definitely a "sweeping monk".

In April 2013, Netease Cloud Music was launched, and people said that Netease Cloud Music was "willing to be cannon fodder".

Because the predecessor of Baidu Music Qianqian Jingting was established in 2003; Cool dog music was founded in 2004; QQ Music was founded in 2005; Kuwo Music and Xiami Music were established in 2006; Tiantianyingmei was founded in 2008 …

When Netease Cloud Music entered the market, cool dogs and QQ music were already big names, and shrimp was not weak. But in this crack, Netease Cloud Music still made 100 million users in two years; Made 200 million users in 3 years; Three years after its launch, Netease Cloud Music also killed Xiami Music, Everyday Music, Douban Music (FM), Domi Music, Baidu Music and Kuwo Music, ranking third in the music category, with only QQ Music and Cool Dog ahead.

Why? Because Netease has seized the dividend of the mobile Internet era-socialization. During the cold start, Netease Cloud Music started a function of importing songs and downloading them for free, which attracted a large number of users of Douban FM and Shrimp at a very low cost.

From the beginning, Netease Cloud Music didn’t intend to be just a "quiet" music player. Instead, we let go of the right to comment on every song, album, song list and mv, giving users a lot of room to play, listening to songs and writing comments, a simple community function, which has captured users.

If we want to evaluate the development of Netease Cloud Music, its success in music APP is just like Pinduoduo’s surprise attack on Taobao.

Although I caught a late episode, I gained a lot. However, late episodes certainly have shortcomings. From the beginning, Netease Cloud Music did not seem to pay too much attention to the importance of "copyright" for itself.

But at that time, the music copyright market was already divided into three parts:

Source: Online public information.

Moreover, compared with Netease Cloud Music, other online players and copyright distribution; There are artist brokers, performance activities and integrated marketing offline, all of which are not just music.

Tencent Music is even richer in the acquisition of copyright. Before Netease Cloud Music reacted, Tencent bought almost all the music copyrights in the world. For example, Tencent is the exclusive agent of Warner, Universal and Sony. There are also the agency rights of companies such as Emperor, Fumao and Jewell.

When Tencent Music was interviewed by the media, it was evenTo say: "We don’t want to monopolize, but they can’t afford it", we can see how strong Tencent’s dominance is.

However, I never expected that Baidu Music had disappeared a few years later, and Ali had closed the shrimp bet.Netease cloud. There are only two forces in the music market, one is Tencent Music, and the other is Netease Cloud.

Although the disparity in strength is relatively large, Netease Cloud actually filled the audience with a grid of electricity like Duanfei in the biography of Zhen Huan.

What’s more, due to the plundering of users’ time by short videos, Tencent Music had 615 million monthly users in the first quarter of 2021, down 6.4% year-on-year. Since last year, the monthly activities of Tencent Music have been declining.

Source: Tencent Music Financial Report

In contrast, from 2018 to 2020, the monthly users of online music services of Netease Cloud Music were 105 million, 147 million and 181 million respectively, which also showed a continuous growth trend, and the compound annual growth rate was 31%; In addition, the number of online music paying users is also rising, reaching 4.2 million, 8.63 million and 16 million respectively, with a compound annual growth rate of 95%.

So if you want to say that Netease Cloud Music is not competitive, then someone will definitely not agree.

　Why did Ali and Baidu bet on a company with negative gross profit margin?

The online music market in China is almost the one with the highest "monopoly" of Tencent except WeChat in the social field. Since Tencent "wooed Cool Dog" and "Cool Me", no one can shake the position of the market leader. This is not to blame Tencent Music. It acted too early and did not give others a chance to surpass it.

There are still fast hand vibrato in the short video field; There are Taobao, JD.COM and Pinduoduo in the field of e-commerce; Iqiyi and Tencent video in the field of long video (film and television drama).

Netease cloud music is preserved like a "kindling", and its strategic shareholders includeAlibabaAnd Baidu, Ding Lei personally served as executive director and CEO. In addition, when the shrimp was shut down at the beginning of this year, Netease Cloud also inherited a large amount of "legacy" of shrimp.

It can be seen that on the music track, the big brothers attach importance to Netease Cloud.

Of course, the bosses can see that Netease Cloud Music does not make money. Supporting it is definitely not just about feelings, mainly because Netease Cloud Music and Tencent Music are still very different in essence.

From the perspective of revenue composition, Netease Cloud Music once paid more attention to online music services. In 2018, the revenue of this sector reached 1.026 billion, accounting for 89.4% of the total revenue. Social entertainment services and other businesses only contributed 122 million yuan in revenue, accounting for a very small proportion of the total revenue. This shows that Netease Cloud Music was still a "teenager with a musical dream" three years ago.

Source: Netease Cloud Music Prospectus

The social entertainment and other income of Tencent Music has always accounted for about 70-80% of the revenue, and the contribution of online music services is only 20-30%. Focus: Tencent Music has made a profit.

In order to increase income, Netease Cloud has also begun to increase the income of social entertainment services and other businesses, and speaking people’s words is to rely on rewards.

Rewarding is always the most effective way to generate income on the Internet. By 2019, the income of Netease Cloud Music Social Entertainment Service and other parts soared by 343.44%, reaching 541 million yuan; In 2020, social entertainment services will once again increase this part of revenue to 2.273 billion yuan with a growth rate of 320.15%, and the proportion of revenue will increase to 46.4%.

At this point, the revenue structure of Netease Cloud Music is gradually balanced in the eyes of capital.

In addition, in 2020, the monthly ARPPU (income per paying user) of Netease Cloud Music in the social entertainment field reached 573.8 yuan, which can be described as "high and scary", but in the same period, the amount of its online music service was only 8.4 yuan, with a gap of nearly 70 times (it seems that making music really doesn’t make money), and the monthly ARPPU of Tencent Music.It is 141.1 yuan.

In other words, the value of a paying user watching live broadcast on Netease Cloud Music is equal to the value of four paying users of Tencent Music, which is the reason why the big brothers are optimistic about the momentum of Netease Cloud Music.

The brilliance of Netease Cloud Music is once again reflected. Who said that the community is useless? Its community stickiness is easy to have a heavy effect in rewarding, while Tencent music must be accumulated through time.

Since its establishment, Netease Cloud Music has received three rounds of financing:

　Source: Online public information.

Among them, in April 2017, it happened to be the day when Netease Cloud Music broke through 300 million users, and accessed Mango and SMG to obtain some pan-entertainment copyrights; In October 2018, it happened to be the moment when Baidu was in all in AI and allowed small speakers to grab the market independently. After joining Baidu, Netease Cloud could get the coveted Taihe copyright.

Here, let’s take a look at Taihe Music Group, which is the "music copyright dynasty" in mainland China besides the big three, Fumao and Emperor. Taihe owns a company called ocean butterflies, and Vae, the big three QQ music company, has joined ocean butterflies for more than 10 years. The elephant intangible music, which is a partnership between Silence Wang and Xu Liang, is also distributed by ocean butterflies in the mainland. Boy, I didn’t expect the big three QQ music companies to become half Netease cloud music people.

In September 2019, Ali won the koala and Netease Cloud Music, and the same year was also the moment when Netease Cloud ARPPU broke out.

Judging from the time nodes of these investments, Netease Cloud really bears the "music renaissance" plan of Ali and Baidu.

　If you want to make money, don’t be a second-hand dealer.

Even Baidu and Ali are desperate for blood transfusion. In terms of copyright, Netease Cloud Music is still in a weak position.

There was such a hot comment in the comment area of Netease Cloud Music, which impressed the author deeply: "I like this community very much. There are touching comments, song lists with personalized recommendations, and bosses full of ghosts, but I finally turned on QQ music because … I want to listen to songs."

Netease Cloud Music has a very high user viscosity and feelings, and the other has a very high resource library and copyright, so the two sides are locked in a fight for users.

At first, the National Copyright Administration seemed to want to give Netease Cloud Music a chance. In October 2015, the National Copyright Administration promoted the strategic cooperation between Netease and Tencent, and QQ Music granted 1.5 million music copyrights to Netease Cloud Music.

However, these 1.5 million songs did not bring reconciliation, but made the record companies in the copyright war suddenly have the right to speak, and the copyright fees also rose, and the online music platform had to fall into an evil.Sexual cycle: buy copyright to attract users → get user traffic and membership benefits → buy copyright again → suck traffic again.

In essenceGenerally speaking, this cycle is not much different from the "second-hand peddler" who pours watermelons at the head of the village, and the right to speak is not in his own hands. The copyright fee is also a "big killer" that has always caused Netease Cloud’s gross profit margin to be negative and lost 7 billion yuan in the past three years. If Netease Cloud wants to make money in music, there is only one way to go-to be the "father" of the record company.

The position of the online music platform in the music market now is equivalent to the ancient "video store", but the video store at least has bargaining space for purchasing goods, but the music platform does not. Therefore, only by getting involved in music production and disintermediation can the music copyright be directly in your own hands and reduce the commercial pressure.

In terms of user quality, Netease Cloud Music should have a lot of music consumption potential, because it currently has 181 million people a month, 89% of whom were born in 1990 and later, and it has Netease’s social genes and a strong social atmosphere.

On the production side of music, the platform can help the pricing and distribution of music copyright, and the reference information is divided into the author’s mode, which adopts the guaranteed+divided mode; On the sales side, the music platform can also sell music copyrights or distribute and underwrite music, such as accessing advertisements, pre-installing mobile phone terminals, smart speakers, smart cars, providing music for short videos, games and other companies, etc. This is the direction for music to make money.

Although Netease Cloud has begun to take this road, it is a long way to cultivate a Jay Chou who can take away tens of millions of users among its original musicians, and it depends on luck. After all, it took decades for the Chinese music scene to produce a Jay Chou.

Of course, if this road goes well, the future music platform will not have to bear the pressure of high copyright fees, and at the same time it will be able to share the cake in the music copyright market. Independent musicians are also expected to earn the dividend of paying for listening to songs, and the entire music industry chain will be boosted.

　Netease Cloud lost Jay Chou, but Netease Cloud "Jay Chou per capita".

After losing the copyright, Netease Cloud Music can make money for music projects by cultivating independent musicians and community culture, which can achieve the effect of "Netease Cloud is Jay Chou per capita", which may be its best result on the music road.

But Netease Cloud Music is still a tangled body in the eyes of many users.

What do users hate most? I hate you talking about money with him, especially users in minority communities, such as Douban, and Netease Cloud Music, which has a seven-point ideal and three-point business. Users who don’t hate you talking about money with it will stare at how you spend money. For example, some users vomit: "Netease Cloud Music does H5 to spread every day. Isn’t it good to buy two more songs with that money?"

Therefore, Netease Cloud Music should balance the user’s experience and the crux before the money-making project, so as to prevent users from losing because they feel that Netease Cloud Music "lost its original heart", otherwise, not to mention the Jay Chou per capita, even the effect of Pangmailang per capita will not be realized, after all, the community is still very pure.

In addition, for Tencent Music, which is listed on the US stock market, the highest price of Netease Cloud listed on the Hong Kong stock market is as high as HK$ 330, while the current share price of Tencent Music is only a dozen dollars. In the music market, is "Jay Chou per capita" overvalued? Or is owning Jay Chou undervalued? Let investors vote.

　　Soda music has a series of functions, such as listening to songs online and downloading songs. If you want to set some preferences or modify some settings in soda music, you can take a look at the soda music setting entrance brought by Xiaobian, which will make it easier for you to set up.

　　First, click [My] in the lower right corner of the soda music software page;

　　The icon in the upper right corner of my page is Settings.

　　The above is the software information brought by IT Encyclopedia Xiaobian. Please pay attention to IT Encyclopedia for more exciting.

　　Cctv news: According to the message of "Healthy Hangzhou" on WeChat WeChat official account. On July 15th, the Hangzhou Municipal Health and Wellness Committee issued the "Circular on the Preliminary Investigation of Medical Accidents in Huayan Medical Beauty Hospital", which pointed out that after the expert evaluation organized by Hangzhou Medical Association, the death of liposuction infection in Hangzhou Net Red Wear was a medical accident. The full text of the bulletin is as follows:

　　On May 2 this year, Dai Moumou went to Huayan Medical Beauty Hospital for liposuction and other medical beauty operations. After the operation, he developed septic shock, and was fully treated by Greentown Hospital and Zhejiang Second Hospital, and finally died on July 13.

　　According to the expert evaluation organized by the Municipal Medical Association, this is a medical accident. Huayan Medical Beauty Hospital has some faults such as lack of understanding before operation, improper operation during operation, untimely observation and treatment after operation, etc., which has a causal relationship with the patient’s death, and has taken full responsibility and made compensation. At the same time, the Xihu District Health and Health Bureau imposed warnings and fines on the hospitals involved, instructed them to suspend business for rectification, and further dealt with the responsible medical staff.

　　Our city will draw inferences from this medical accident, strengthen the practice management of medical institutions, and intensify the rectification of medical beauty chaos.

FAW Toyota Corolla Twin Engine 1.8L Elite Edition is a hybrid vehicle produced by FAW Toyota, belonging to Corolla series. This car adopts Toyota’s Hybrid Synergy Drive(HSD) hybrid technology, which combines a 1.8-liter naturally aspirated engine with an electric motor to achieve higher fuel economy and lower emissions.

In terms of configuration, FAW Toyota Corolla Twin Engine 1.8L Elite Edition is equipped with luxury configurations such as navigation system, reversing image, automatic air conditioning, electric seat adjustment and multi-function steering wheel. In addition, the car also has intelligent key, one-button start, automatic headlights and other functions, which brings a more convenient driving experience for drivers.

In terms of safety performance, FAW Toyota Corolla Twin Engine 1.8L Elite Edition also performed well. The car is equipped with Toyota Safety Sense Zhixing safety suit, including pre-collision system, lane departure warning system, adaptive cruise control system and other active safety functions, which effectively reduces the safety hazards during driving.

Generally speaking, FAW Toyota Corolla Twin Engine 1.8L Elite Edition is a hybrid car with both power performance and fuel economy, which is suitable for consumers who pay attention to environmental protection and energy saving.

The original distressing Jiushu 39 Health Network

In the group match of Asian Youth Badminton Championship on June 30th, 17-year-old Zhang Zhijie of China Badminton Team suddenly fainted and died after being sent to hospital for rescue.

According to the press conference of Indonesian Badminton Association on July 1st, the treatment and examination results of Air Force Central Hospital and Central General Hospital showed that Zhang Zhijie died of sudden cardiac arrest.

In the face of sudden bad news, many teammates of Zhang Zhijie expressed their condolences over his death. Some teammates said that "Zhang Zhijie was in good health at ordinary times and had never heard of any diseases".

The death of such a young and promising child is really sad, and his departure also reminds us that even people who seem to be healthy at ordinary times may die suddenly.

This has a great relationship with the reasons behind sudden cardiac arrest.

Cardiac arrest refers to the sudden stop of the heart, which leads to the interruption of blood circulation, and the organs of the body can not get enough oxygen and nutrition. If not rescued in time, the patient will soon die.

This is often the main cause of sudden cardiac death.

According to China Cardiovascular Disease Report, about 544,000 people die of sudden cardiac death (SCD) every year in China, which is equivalent to one person dying of cardiac arrest every minute.

Because of the rapid onset and unpredictable onset time of sudden cardiac death, sometimes people around you will be gone before they can react, so it is very important to understand its inducement, symptoms before coming and preventive measures.

Although sudden cardiac death is urgent, it is not completely untraceable. Today, Uncle Jiu came to explore the "trace" of sudden death.

During strenuous exercise, the myocardial oxygen demand increases, which will aggravate the heart load. If the cardiovascular function is inherently impaired, it is easy to cause oxygen imbalance, myocardial necrosis, and eventually lead to sudden cardiac death.

In addition, long-term or strenuous exercise may also lead to a lot of sweating, which in turn leads to electrolyte imbalance, especially the loss of potassium and sodium ions, resulting in hypokalemia.

Once patients with myocardial infarction are complicated with hypokalemia, it is easy to cause malignant arrhythmia, such as ventricular tachycardia or ventricular fibrillation, which leads to a sharp drop in blood supply and even cardiac arrest. Sudden cardiac death is easy to occur if the rescue is not timely.

Clinical data show that hypokalemia is the most common cause of sudden death in badminton or marathon.

A study of 5,516 cases of sudden death in chinese journal of critical care medicine in 2020 found that sudden cardiac death was the primary cause of sudden death, accounting for 57.76%.

The second place is emotional excitement, accounting for 25.66%.

When angry, the blood flow of the heart doubles than usual, the contractility of the heart is strengthened, the heartbeat is accelerated, and a large amount of blood rushes to the heart, which is easy to induce angina pectoris and myocardial infarction, and then lead to sudden death.

Modern people have a fast pace of work, great pressure in life, and often stay up late to be a demon, which is easy to make their bodies overworked.

At this time, the body will continue to be tense, the nervous system is also highly tense, and the sympathetic nerve has been stimulated, thus raising blood pressure and increasing the burden on the heart.

Overwork can also lead to an increase in heart rate and increase the oxygen consumption of the heart, which may lead to acute myocardial infarction in severe cases and then sudden cardiac death.

Sudden cardiac death is closely related to heart problems, so people with cardiovascular diseases are more likely to be targeted.

If suffering from coronary heart disease, it will cause myocardial infarction, leading to myocardial necrosis and cardiac dysfunction;

Cardiomyopathy makes the structure and function of myocardium abnormal, which increases the risk of arrhythmia and sudden cardiac arrest.

Severe arrhythmia, such as ventricular fibrillation and ventricular tachycardia, can make the heart lose its effective pumping function, lead to insufficient blood supply and eventually lead to sudden death.

Conditions such as congenital heart disease and myocarditis can also lead to similar heart events.

Therefore, people with basic diseases should especially take care of their hearts.

For young people, the main causes of exercise-induced sudden death are coronary heart disease and hypertrophic cardiomyopathy. In addition, excessive tension, excitement, fatigue and other factors will also increase the risk of sudden cardiac death in young people.

Middle-aged people, especially those aged between 30 and 63, are often at high risk of sudden cardiac death. Because of the pressure of work and life, staying up late and working overtime, irregular diet and other factors, they are more prone to coronary heart disease.

Older people are more susceptible to myocarditis, heart failure and other diseases, which will lead to the gradual decline of heart function, thus increasing the risk of sudden cardiac death.

Although sudden death is urgent and heavy, it often sends us a distress signal before it happens, which must not be ignored.

If you have severe, tight and crushing pain in your chest, you need to be vigilant when you feel like your chest has been squeezed repeatedly and you feel suffocated.

Chest pain is also a typical manifestation of coronary heart disease, which generally occurs behind the sternum. More attention should be paid to this situation.

Our emotions will also protect our bodies. If there is a sense of panic at this time, don’t ignore the "alarm" of your body. No matter what you are doing, stop and observe immediately.

In addition to chest pain, in the absence of injury or illness, shoulders, chin, throat, teeth appear pain, and sometimes feel depressed, this situation should also be vigilant.

If a patient with hypertension suddenly has severe headache or even vomiting, it is necessary to highly doubt whether a cerebrovascular accident has occurred, and beware of sudden death.

In addition to pain, if there are obvious cyanosis, purple lips and decreased blood oxygen, it is highly doubtful whether there is pulmonary embolism.

Acute pulmonary embolism, if not handled properly in time, will easily lead to pulmonary infarction, blood circulation disorder and sudden death.

On the premise of no lack of sleep, strenuous exercise or illness, there is an unrelenting sense of fatigue for days, weeks or even months.

And accompanied by insomnia, anxiety, waking up at night and other symptoms, it is necessary to consider whether there is a heart problem.

Before sudden cardiac death, many patients will have a lot of cold sweat, which is one of the typical manifestations of myocardial infarction.

If you don’t have a history of heart disease, but suddenly you have sweating, palpitation, chest pain and other symptoms, you must not be careless, and you must see a doctor in time.

First of all, take responsibility for your health.

Maintain healthy living habits, feel your physical condition with your heart, and be alert to every alarm signal.

When you feel chest tightness, chest pain, dizziness and unknown pain, it is the body that reminds you that it is time to rest. Don’t sacrifice your life in pursuit of temporary efficiency.

Sedentary people should also pay attention to standing up and walking every hour or two, which can effectively promote blood flow in the legs and avoid pulmonary embolism.

Second, pay attention to your emotions.

If you know that you are angry, angry, grumpy and emotional, you should control it properly and find the right way to relieve your emotions.

Take things slowly, sometimes it will be faster.

If you find that you have signs of sudden death, don’t panic, rest quietly first, lie down when you are comfortable, and sit when you are comfortable, but don’t move unless necessary.

If there is oxygen inhalation equipment nearby, you should take oxygen as soon as possible with the help of your family or people around you.

At the same time, take the first-aid medicine that you carry with you immediately, such as chewing nitroglycerin and putting it under your tongue.

Patients with angina pectoris can usually relieve their pain in about two minutes. If the effect is not good, they can take a piece of nitroglycerin under their tongue 10 minutes later and call 120 emergency number quickly.

Finally, if you have spare capacity, you may be able to do your part by learning some first-aid skills when people around you suddenly fall to the ground and have signs of sudden death.

A report published in Military Medical Research shows that after cardiac arrest, the recovery rate of heartbeat can reach 41.7% if the rescue time is within 0~5 minutes; However, if the rescue time is within 5~10 minutes, the recovery rate of heartbeat is only 14.3%.

Therefore, in the first aid of sudden death, there has always been a saying of "golden four minutes". If we can grasp these few minutes, it is likely to save a life.

First aid can be done according to the following methods:

First of all, don’t carry or shake the patient, let him lie on his back on the ground, then pat the patient on the shoulder and call ta loudly.

Then observe the patient’s breathing: whether there is wheezing or abnormal breathing in the chest or abdomen (no more than ten seconds).

At the same time, touch the carotid artery for pulsation (non-medical personnel do not need to judge). At the same time, call for help loudly, and designate the personnel present to dial 120 emergency number. When there are no personnel present, call them quickly and keep effective communication with the medical staff in the emergency center.

If the patient is unconscious and his breathing and pulse disappear, chest compressions and artificial respiration should be performed immediately.

Pressing method: straighten your arms, one palm is close to the patient’s chest wall, the other palm is placed on the back of this hand, your fingers are crossed and held up, and the roots of your palms are forced.

Pressing position: the midpoint of the connecting line between the two nipples.

The compression amplitude and frequency are: the sternum sinks 5 ~ 6 cm (adult), and the chest fully rebounds after each compression, and the hands do not leave the chest wall, and the frequency is 100 ~ 120 times/minute.

按压时间与放松时间各占一半，放松时掌根部不要离开胸壁，以免按压点移位。

必要时进行人工呼吸：清理气道异物，仰头提颏法开放气道，一手捏鼻，嘴巴张大包紧患者嘴唇进行缓慢持续1秒钟吹气，吹气时余光观察患者胸廓是否微微起伏，放松捏鼻再次进行吹气。

按压和通气比例为30∶2，按压30次，人工呼吸2次，按压和人工呼吸5个循环后重新评估患者的意识、呼吸和脉搏。

*注意在开放气道的同时应用手指挖出病人口中异物或呕吐物，如有假牙者应取出假牙。

最后，如果旁边有自动体外除颤器（AED）就最好了。

设计AED的初衷就是让任何一个人都能毫无门槛地操作。因为情况紧迫，没有给人看说明书的时间，所以打开电源开关后，AED都是有语音提示的。

最后的最后，虽然九叔写文辛苦，但真心希望大家在生活中不会遇到上面的情况。

参考资料：

[1]赵智梅，陈晓松，杨仪君，杜鹏举，周攀豪. 我国5516例尸解猝死病例流行特征分析[J]. 中国急救医学, 2020, 40(2): 158-16

[2]王乾,赵丽. 心脏性猝死的研究进展[J]. 中华急诊医学杂志,2021,30(11)：1407-1409.

[3] Health first aid science teaches you to learn to use the life-saving artifact AED. Xinhuanet.2023-04-20.

[4]Gu XM, Yao SB, He ZJ, et al. Meta-analysis of the success rate of heartbeat recovery in patients with prehospital cardiac arrest in the past 40 years in China.Mil Med Res. 2020; 7(1):34.

[5] All sudden deaths are planned for a long time! We must pay attention to the six signals sent by the body. Wuxi CDC .2022-08-02.

[6] Guo Yu teenager Zhang Zhijie passed away after fainting. Emergency expert: Three life-saving links were missed at the scene. Upstream news .2024-07-01.

[7] After dissecting more than 5,000 cases of sudden death, doctors found that people who died suddenly had these rules! . Health Times. 2020-08-06.

[8] How to give first aid to patients with sudden cardiac death? Keep these four steps in mind. Healthy China. 2023-10-09.

Original title: "Dissecting 5516 cases of sudden death, discovering the law of sudden death: people who are prone to sudden death have four things in common"

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The original Singularity Cake Singularity Network is included in the collection # 50 Sports.

* For medical professionals only.

In addition to improving body muscle shape, exercise is more an effective health intervention, which is related to the reduction of the risk of chronic metabolic diseases such as obesity, diabetes and cardiovascular diseases.

However, it is easy to say that "exercise is good for physical and mental health", but it is difficult to explain the mechanism. There are still many unsolved mechanisms of exercise on systemic metabolic health. For example, a recent study shows that, but researchers have not directly proved the specific benefits of exercise to the liver [1].

This time, the team of He Congcong from Northwestern University found that the initiation of liver autophagy is a key link for exercise to bring systemic metabolic benefits.

Their research shows that exercise causes muscle to release a signal molecule called fibronectin 1(FN1), which reaches the liver through blood circulation and acts on α5β1 integrin on the surface of liver cells, thus triggering autophagy in the liver, thus improving metabolic health problems such as insulin sensitivity [2]. The article was recently published in the journal Cell Metabolism.

Screenshot of the first page of the paper

Autophagy abnormality has been considered to be related to many metabolic disorders in recent years. Previous studies have shown that exercise can induce autophagy in skeletal muscle of mice or humans through energy stress, oxidative stress and increase of intracellular Ca2+ level. In addition to these muscle tissues, many studies have shown that exercise can also activate autophagy in non-contractile muscle tissues such as liver, pancreas and adipose tissue, but the mechanism is still unclear [2].

Therefore, He Congcong and others deeply explored whether exercise can unlock the autophagy pathway of the liver and its role in systemic metabolic health.

First of all, they constructed a group of mouse models (ATG7Δliver) in which autophagy gene ATG7 was specifically down-expressed, so as to inhibit autophagy in liver cells.

Under the regular diet, the metabolic indexes of these mice are similar to those of wild-type mice. However, in the case of high-fat diet and running for 50 minutes every day, after 7 weeks, although the weight of the two groups of mice was similar, unlike wild-type mice, exercise did not save the glucose tolerance and insulin sensitivity of ATG7Δliver mice under high-fat diet.

These indicate that the improvement of metabolic health by exercise depends on autophagy of liver cells.

Exercise can’t save at G7 δ liver mice.

The results of in vitro experiments show that plasma and serum of wild-type mice can activate hepatocyte autophagy when they are in exercise, but plasma or serum at rest can not. In other words, there is a switch in the blood to turn on the autophagy pathway of the liver.

After protein’s proteomic analysis of the blood of mice, the researchers found that the level of fibronectin (FN1), an extracellular matrix protein that can be expressed by many types of cells, increased significantly in the blood of wild-type mice after exercise.

In addition, the experimental results in vitro showed that adding activator of AMPK, a cell energy sensor, to the culture medium could induce muscle cells to secrete FN1, but could not induce liver cells to secrete FN1. This suggests that the level of FN1 in blood is regulated by AMPK, and exercise may activate AMPK in muscle.

In the exercise state (when AMPK is activated), the extra FN1 comes from muscle cells, not liver cells.

In order to further study the role of muscle-derived FN1 in exercise, researchers specifically depleted FN1 (FN1(FN1Δmuscle) in mice muscles.

The results showed that the level of FN1 in the blood circulation of FN1Δmuscle mice did not increase after wheel running. Compared with wild-type mice, these mice did not get the improvement of systemic insulin sensitivity caused by exercise.

Specifically, the exhaustion of muscle-specific FN1 in mice did not affect its exercise-induced muscle autophagy, muscle morphology and exercise ability, and at the same time, the improvement of exercise-induced insulin signal transduction (activation of Akt regulatory factors) could be observed in its muscles. However, in this group of mice, the exercise-induced liver autophagy pathway was not activated, and no improvement in exercise-induced insulin signal transduction was observed in the liver.

These indicate that FN1 released by muscle is very important for the initiation of liver autophagy during exercise.

The depletion of FN1 in muscle affects liver autophagy.

From the mechanism point of view, during exercise, muscles secrete FN1, which leads to the increase of FN1 level in blood circulation. FN1 binds and interacts with α5β1 integrin in liver, activating IKK-JNK1-BECN1 signal pathway in liver cells, thus starting liver autophagy, promoting liver autophagy and reducing liver fat accumulation.

If the expression of α5β1 integrin in the liver of mice is inhibited, the weight, glucose tolerance and insulin sensitivity of mice can not be improved after high-fat diet and exercise, which proves the importance of α5β1 integrin -IKK-JNK1 pathway for the benefit of exercise-induced metabolism.

Overall, this study completed by He Congcong’s team shows that liver autophagy plays a key role in exercise-induced metabolic benefits, and reveals its mechanism. In addition, this study also shows that the metabolism of non-contractile muscle tissues such as liver can also be regulated by muscles.

References:

[1]Stine, J. G., DiJoseph, K., Pattison, Z., Harrington, A., Chinchilli, V. M., Schmitz, K. H., & Loomba, R. (2022) . Exercise Training Is Associated With Treatment Response in Liver Fat Content by Magnetic Resonance Imaging Independent of Clinically Significant Body Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. The American journal of gastroenterology, 10.14309/ajg.0000000000002098. Advance online publication. https://doi.org/10.14309/ajg.0000000000002098

[2]https://www.sciencedirect.com/science/article/abs/pii/S1550413123000116

The author of this article is Zhang Aidi

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Although there are only three models on sale at present, its M5/M7/M9 models are the top "players". For example, can you imagine a large SUV with a price of more than 470,000, but in May, it obtained the report card of sales data of more than 16,400 new cars? Therefore, with the empowerment of Huawei, the brand of the world can indeed be called a soul, which is exactly what other car companies envy.

No, after the new model, the new model and the customer M9, the customer brand will soon launch a brand-new customer M8 model. The new car is expected to provide a 5/6 seat layout, and the price we guess will start at around 350,000 ~ 400,000. If the price forecast comes true, then there will undoubtedly be opponents in this price range. Let’s take a brief look at it.

Judging from the spy photos exposed, the appearance of the asking world M8 is basically the same as that of the asking world M9. It is also an iconic family-style front face design and a penetrating taillight. The overall visual perception is not much different from that of the asking world M9, but it is slightly smaller than that of the asking world M9 in terms of volume sense, which is also the reason why the positioning of the two models is different.

The picture shows the M9 extended range version (left) and the pure electric version (right).

As for the interior, the M8 is expected to adopt the same interior design as the M9. The center console is composed of a large LCD screen, which looks highly integrated, and the interior should also be equipped with Huawei’s latest HarmonyOS cockpit.

Other configurations, such as rear projection, car refrigerator, 25-speaker HUAWEI SOUND sound system and ADS 3.0 smart driving, should also be available, so I don’t think friends who care about configuration and functionality need to worry too much. This M8 can definitely give it to you.

In terms of power, if there is no accident, the M8 should also provide extended range version and pure electric version for selection. Taking the M9 as a reference, its extended-range model is equipped with a 1.5T turbocharged engine and two front and rear motors, with a total power of 496 HP and a total torque of 675 Nm. The battery CTLC has a pure electric cruising range of 225km and 275km.

The pure electric version of the M9 is more simple and rude. The total power of the dual motors is 530 HP, and the maximum torque is 673 Nm. In terms of battery life, the CLTC of the pure electric version M9 has a pure electric cruising range of 630km and a battery capacity of 100kWh, using batteries from Contemporary Amperex Technology Co., Limited. However, there are only two versions of the pure electric version, and the lowest starting price has reached 509,800, so most users may still buy the extended-range version.

Finally, there is no doubt that the market share of the ideal L8 must be threatened by the arrival of M8. After all, regardless of the price, size, configuration and power form, the M8 seems to be chasing the ideal L8. Therefore, if this new car is really sold at a price of less than 400,000, then the ideal L8 obviously has a strong opponent.

In a word, the brand of Jiejie, which is empowered by Huawei, has already begun to show its edge. With the coming of another new model, Jiejie M8, we also believe that the new car will definitely catch fire after it goes on the market, don’t you believe it? Then let’s wait and see ~ (Text/Youshi Automobile Dazhuo)

Note: The pictures are from the Internet, and the rights belong to the original author. If there is any infringement, please contact and delete them. Thank you! This article only represents the author’s personal views, and does not represent the position of AUV.