Notice on Issuing the Code of Practice for Strengthening the Immunity of Highly Pathogenic Avian Influenza

In order to effectively prevent the occurrence of highly pathogenic avian influenza epidemic and guide all localities to do a good job in immune prevention of highly pathogenic avian influenza, our department has formulated the "Code of Practice for Strengthening Immunity of Highly Pathogenic Avian Influenza". It is issued to you, please follow it.

Attachment: Operational Specifications for Strengthening Immunity of Highly Pathogenic Avian Influenza

The Ministry of Agriculture of the People’s Republic of China

November 11th, 2005

Operational norms for strengthening immunity of highly pathogenic avian influenza

Highly pathogenic avian influenza is caused byAAn acute and highly infectious disease caused by highly pathogenic strain of avian influenza A virus can not only cause huge economic losses to poultry industry, but also may cause serious public health problems. To do wellH5The prevention and control of subtype highly pathogenic avian influenza, to ensure the immune density, improve the protection of poultry groups, and prevent the outbreak, is formulated in accordance with the provisions of the Law of People’s Republic of China (PRC) on Animal Epidemic Prevention.

First, the scope and requirements of immunization

Compulsory immunization should be carried out for all poultry, and the immunization density should reach100%(except poultry with special requirements that need not be immunized).

Second, the vaccine used for immunization

The avian influenza vaccine approved by the Ministry of Agriculture must be used. At present, the Ministry of Agriculture has approved the production ofH5Subtype avian influenza vaccines are:

Recombinant inactivated avian influenza vaccine (H5N1Subtype,Re-1Strain); Avian influenza recombinant fowlpox virus vector live vaccine (H5Subtype); Inactivated avian influenza vaccine(H5Subtype,N28plant); highly pathogenic avian influenza (HPAI)H5(N28plant)– H9Bivalent inactivated vaccine.

For the storage, transportation, use method and dosage of the vaccine, please refer to the instruction manual of the vaccine and the technical specification for immunization of highly pathogenic avian influenza.(NY/T 796-2004).

Third, the operating norms of immunization

(1) Routine immunization

one. Breeding chickens and laying hens:14At age, inactivated recombinant avian influenza vaccine was used.(H5N1Subtype,Re -1plant)Or inactivated avian influenza vaccine.(H5Subtype,N28plant)For the first time, intervalthreeAfter a week, another booster immunization will be conducted, and everysixCarry out next monthoneSecondary immunization; Avian influenza recombinant fowlpox virus carrier live vaccine can also be used.(H5hypotype)Initial exemption, intervalthreeAfter weeks, the recombinant inactivated avian influenza vaccine (H5N1Subtype,Re-1Strain) or inactivated avian influenza vaccine (H5Subtype,N28Strain) to strengthen immunization once, after everysixNext month, use recombinant inactivated avian influenza vaccine (H5N1Subtype,Re-1Strain) or inactivated avian influenza vaccine (H5Subtype,N28Strain)oneSecondary booster immunization.

2Commercial broiler:10～14At the age of day, live vaccine with recombinant fowlpox virus vector of avian influenza (H5Subtype)oneSecondary immunization is enough (chickens without maternal antibodies can be immunized atoneImmunization with avian influenza recombinant fowlpox virus carrier live vaccine at the age of 18).

threeDuck:14At the age of 10, the recombinant inactivated avian influenza vaccine (H5N1Subtype,Re-1Strain) or inactivated avian influenza vaccine.(H5Subtype,N28plant)For the first time, intervalthreeWe’ll do it in a weekoneThe second booster immunization, after each.sixCarry out next monthoneSecondary booster immunization.

fourGoose:14At age, inactivated recombinant avian influenza vaccine was used.(H5N1Subtype,Re-1plant)Or inactivated avian influenza vaccine.(H5Subtype,N28plant)For the first time, intervalthreeWe’ll do it in a weekoneThe second booster immunization, after each.fourCarry out next monthoneSecondary booster immunization.

fiveOther birds: immunize according to the instructions for vaccine use or refer to the above requirements.

(2) Immunization of free-range poultry

Every spring and autumn, a comprehensive centralized immunization is carried out according to the immunization program.

(3) Immunization of poultry in border areas

On the basis of routine immunization, border provinces are far from the border when threatened by the epidemic situation in neighboring countries.thirtyAll border counties within kilometers should carry out a booster immunization for all poultry.

(4) Migratory bird activities and poultry immunization in areas with dense water networks.

Combined with routine immunization, before the arrival of migratory birds’ migration season, all poultry should be given a booster immunization.

(5) Immunization of poultry in threatened areas

After the outbreak, all poultry in the threatened area should be given a booster immunization.

Note: In the above scheme, avian influenzaH5(N28plant)– H9The use of bivalent inactivated vaccine can be compared with avian influenza inactivated vaccine.(H5Subtype,N28plant)Same.

Iv. monitoring of immune effect

All provinces, autonomous regions and municipalities should formulate local immunization effect monitoring programs to keep abreast of the immunization status of poultry groups.

According to the technical specification for highly pathogenic avian influenza immunization(NY/T 796–2004)Requirements, with hemagglutination inhibition test.(HI)Detect serum antibodies.HIAntibody titer is greater than4log2At that time, it is judged that the immunity is qualified.

The proportion of qualified poultry in the total number of immunized poultry should not be less than70%.